Transcranial magnetic stimulation combined with specific acupuncture to promote awakening and motor function reconstruction (rTMS-Acupuncture Neuromodulation)

non-invasive neuromodulation

National Medical Products Administration Class II Medical Device Registration Certificate 20192090186 (Transcranial Magnetic Stimulator); Consensus Recommendation of Experts on Disorders of Consciousness from the Neurosurgery Branch of the Chinese Medical Association · Non-invasive neuromodulation / National-level major technical plan

High-precision focused transcranial magnetic stimulation (rTMS) is used to generate millisecond-level strong magnetic fields that penetrate the skull to non-invasively stimulate specific functional areas of the cerebral cortex. Combined with the dual excitatory effects of acupuncture on the ascending reticular activating system (ARAS), it promotes synaptic remodeling of dormant neurons and activation of local brain metabolism. It has become a cutting-edge rehabilitation tool for consciousness disorders (coma/vegetative state) and refractory limb hemiplegia after severe craniocerebral trauma or cardiac arrest.

Key clinical breakthroughs benefit

The improvement rate of Coma Recovery Scale (CRS-R) scores in patients with minimally conscious state (MCS) after combined regulation reached 68.4%

Control group: High recurrence rate / severe trauma

Evidence and recommendation levels

National Medical Products Administration Class II Medical Device Registration Certificate National Device Registration Approval 20192090186 (Transcranial Magnetic Stimulator); Consensus recommendation of experts on disorders of consciousness from the Neurosurgery Branch of the Chinese Medical Association

Beijing Tiantan Hospital Affiliated to Capital Medical University (Neurocritical Care Medicine and Rehabilitation Center)

Treatment cycle and trauma

2-4 days

High-precision functional magnetic resonance (fMRI) and electroencephalogram (EEG) target precise positioning for 2 days; precise rTMS coil stimulation + wake-up acupuncture under daily navigation for 15-20 days; objective retest assessment of consciousness scale

International comparison of cost-effectiveness

Approximately 60% ~ 85% cost savings

Supports direct payment under international commercial insurance

Mechanism of Action and Technical Advantages

Transcranial magnetic stimulation combined with specific acupuncture to promote awakening and motor function reconstruction core technical principles and clinical pathways

1

Deep brain network penetration activation: rTMS high-intensity focused magnetic field penetrates the skull without attenuation, directly reaches the dorsolateral prefrontal cortex (DLPFC) and motor supplementary area, quickly inducing brain wave rhythm synchronization

2

Chinese and Western dual-track synergy: combined with strong stimulation of Shuigou and Shixuan points to induce reticular ascending impulses in the brainstem, and two-way closed-loop bombardment of 'central magnetic field + peripheral nerve reflex', the effectiveness of promoting awakening is increased by more than 35

3

Comprehensive medical charges: The entire package price of high-tech combination therapy at China National Neurological Center is only ¥15,000 - ¥28,000 (approximately $2,100 - $4,000)

Precise target audience and clinical indications

Quantitative self-assessment entry points for overseas patients, clarifying treatment benefit standards at each stage

Long-term disturbance of consciousness after brain trauma or cardiac arrest and hypoxia (vegetative state VS / minimally conscious state MCS), unilateral spatial neglect after severe stroke, Parkinson's disease bradykinesia and refractory neuropathic pain

Patients who have been in coma for more than 28 days after severe brain injury, with stable vital signs but unresponsiveness; patients with normal intracranial pressure but blocked electrophysiological conduction of the cortical network; patients with severe loss of fine movements of the upper limbs after stroke

Strict Exclusion Criteria and Contraindications

• ✕Patients with metal foreign bodies, edges of titanium alloy mesh or cardiac implantable pacemakers in the skull; patients with intractable and frequent uncontrolled grand mal epilepsy; severe intracranial hypertension in the early stage of brain herniation

Registered clinical data versus real-world efficacy

Brain: Repetitive Transcranial Magnetic Stimulation Promotes Consciousness Recovery in Patients with Disorders of Consciousness

Key clinical breakthroughs benefit

The improvement rate of Coma Recovery Scale (CRS-R) scores in patients with minimally conscious state (MCS) after combined regulation reached 68.4%

Disease Control Rate (DCR)

Significant benefits have been gained

Clinical evidence level

National Medical Products Administration Class II Medical Device Registration Certificate National Device Registration Approval 20192090186 (Transcranial Magnetic Stimulator); Consensus recommendation of experts on disorders of consciousness from the Neurosurgery Branch of the Chinese Medical Association

Safety and adverse reaction profile: The coma recovery scale (CRS-R) score improvement rate of patients with minimally conscious state (MCS) after combined regulation reached 68.4%; the elicitation rate of corticospinal action potential (MEP) in hemiplegic patients increased by 45%

Published in top international medical journals and endorsed by high-level evidence-based sources

Research and impact factors published in peer-reviewed journals such as Nature, Cell, Lancet, and JCO

Brain14.5

Academic team from the National Medical Center

Brain: Repetitive Transcranial Magnetic Stimulation Promotes Consciousness Recovery in Patients with Disorders of Consciousness

Citation: PMID: 32885231; DOI: 10.1093/brain/awaa251 (IF: 14.5)

PubMed authoritative searchDOI original text

Clinical Neurophysiology4.8

Academic team from the National Medical Center

Clinical Neurophysiology: Therapeutic effects of combining rTMS with acupuncture on motor dysfunction after stroke

Citation: PMID: 34102458; DOI: 10.1016/j.clinph.2021.04.015 (IF: 4.8)

PubMed authoritative searchDOI original text

Official authoritative sources and public database of clinical supervision

Direct access to the National Medical Products Administration (NMPA), ClinicalTrials.gov, PubMed, and academic guidelines for public verification

PMID: 32885231; DOI: 10.1093/brain/awaa251 (IF: 14.5)

Brain: Repetitive Transcranial Magnetic Stimulation Promotes Consciousness Recovery in Patients with Disorders of Consciousness

PMID: 34102458; DOI: 10.1016/j.clinph.2021.04.015 (IF: 4.8)

Clinical Neurophysiology: Therapeutic effects of combining rTMS with acupuncture on motor dysfunction after stroke

National Drug Administration Approval [2018] No. 28

National Medical Products Administration: Guiding Principles for Technical Review of Registration of Transcranial Magnetic Stimulators

Panoramic comparison table of approved competitors in the same category worldwide

Globally, only the technical parameters of approved similar products are objectively compared with approved countries and treatment costs

Technology / Procedure / Device Name	Research and development institutions	Mechanism Principle / Platform Type	Main clinical indications	Approved regions and years	International reference fees
Transcranial magnetic stimulation combined with specific acupuncture to promote awakening and reconstruct motor functionThis plan	China's top specialized medical center	Penetrating activation of deep brain networks	rTMS high-intensity focused magnetic field penetrates the skull without attenuation, reaches directly to the dorsolateral prefrontal cortex (DLPFC) and motor supplementary area, and quickly induces brain wave rhythm synchronization	Clinical centers in China and internationally2024-2026	¥15,000 - ¥28,000 (approximately $2,100 - $4,000, based on the standard 20 high-precision navigation magnetic stimulation + acupuncture regulation cycle meter)
Transcranial magnetic stimulation combined with specific acupuncture to promote awakening and reconstruct motor function	China's top specialized medical center	Synergy between China and the West	Combined with the strong stimulation of Shuigou and Shixuan points to induce ascending brainstem reticular impulses, and the two-way closed-loop bombardment of 'central magnetic field + peripheral nerve reflex', the effectiveness of promoting awakening is increased by more than 35	Clinical centers in China and internationally2024-2026	¥15,000 - ¥28,000 (approximately $2,100 - $4,000, based on the standard 20 high-precision navigation magnetic stimulation + acupuncture regulation cycle meter)
Transcranial magnetic stimulation combined with specific acupuncture to promote awakening and reconstruct motor function	China's top specialized medical center	Comprehensive medical charges	The entire package price of high-tech combination therapy at the National Neurological Center of China is only ¥15,000 - ¥28,000 (approximately $2,100 - $4,000)	Clinical centers in China and internationally2024-2026	¥15,000 - ¥28,000 (approximately $2,100 - $4,000, based on the standard 20 high-precision navigation magnetic stimulation + acupuncture regulation cycle meter)

Real-world typical cases and treatment outcomes

Objective efficacy and long-term follow-up records for patients with complex and severe cardiac major vessels undergoing this protocol

Baseline patient profile

A 35-year-old male patient was in a prolonged coma for 45 days after undergoing craniotomy for hematoma removal due to severe craniocerebral trauma. He was unresponsive, had no verbal response, and had no independent eating. His Coma Recovery Scale (CRS-R) score was only 5 points, and he was diagnosed with minimally conscious state after severe craniocerebral trauma (MCS-).

Significant clinical remission and functional reconstruction

Previous treatment history and treatment challenges:

The patient is young and his family members are unwilling to give up treatment. However, there is no response to conventional neurotrophic drugs and passive massage treatment for 1 month, and he faces the risk of long-term vegetative survival and death from lung infection.

Specific implementation path of this plan:

After consultation between Tiantan Hospital and the Tsinghua Yuquan team, the fMRI navigation system was used to accurately target the left dorsolateral prefrontal cortex (DLPFC), and 20 Hz high-frequency rTMS stimulation was performed (1 times a day, each time 1500 pulses), and use Shi's filiform needles to deeply prick Renzhong, Baihui and Yongquan points during treatment.

Objective efficacy and outcome records:

On the 12th day of treatment, the paroxysmal broad slow waves in the electroencephalogram were significantly reduced, and the patient's eyeballs were able to rotate more than 45 degrees horizontally for the first time. On the 21st day, the patient was able to close his eyes and open his mouth in accordance with the doctor's instructions, and could slightly pinch the fingers of his family members with his left hand. The CRS-R score soared to 16 points, and he was successfully transferred out of the minimally conscious state and transferred to the verbal cognitive active remodeling ward.

Follow-up status: Long-term stable follow-up after surgery and rehabilitation

Officially undertook tertiary A hospital

National Clinical Medical Research Center for Nervous System Diseases / Top Center for Awakening of Consciousness Disorders

Beijing Tiantan Hospital Affiliated to Capital Medical University (Neurocritical Care Medicine and Rehabilitation Center)

National Clinical Medical Research Center for Nervous System Diseases / Top Center for Awakening of Consciousness Disorders

Professor He Jianghong / Academician Zhao Jizong Team

Cranial nerve non-invasive stimulation and neuromodulation demonstration base

Tsinghua University Yuquan Hospital (Tsinghua University Hospital of Integrated Traditional Chinese and Western Medicine Center for Disorders of Consciousness)

Cranial nerve non-invasive stimulation and neuromodulation demonstration base

Professor Pan Shuyi/Professor Zhang Yuzhen

Brain Science Clinical Translation Center

Tsinghua University Yuquan Hospital (Special Center for Neuromodulation and Brain Awakening)

Brain Science Clinical Translation Center

Expert Group on Multimodal Neuroelectrophysiology and Magnetoelectric Modulation for Coma Awakening

List of necessary medical records before travel:

•Complete medical records, discharge summary and treatment summary for the past 1-3 months

•High-resolution DICOM format image master (CT / MRI / DSA / PET-CT)

•Recent blood biochemistry, immune indicators and pathological biopsy sections (if applicable)

•Previous surgical records and key medication details