Chinese medicine fumigation and penetration combined with deep radiofrequency hyperthermia (new solution for ankylosing spondylitis and refractory arthrofibrosis)

Warm meridians chemical fiber targeted penetration

National Medical Device Registration Certificate of the State Food and Drug Administration Class II Medical Device Approval 20182260195 (Deep Radiofrequency Thermal Therapy Machine); Catalog of Technical Specifications for Traditional Chinese Medicine External Treatment · Warm Meridian Chemical Fiber Targeted Penetration / National Major Technical Plan

Integrate the ancient Lingnan method of warming meridians and unblocking collaterals with modern millimeter-wave deep radio frequency physical heat therapy. It uses a fully automatic traditional Chinese medicine constant temperature fumigation chamber to absorb high-concentration transdermal traditional Chinese medicine volatile oils (Tuangucao, Shenjincao, Chuanxiong, Frankincense, etc.) Meter-level ionization penetrates into the deep spinal facet joints and fascial layers. Deep radiofrequency increases the temperature of deep paravertebral diseased tissue to 41-43°C, effectively dissolves fibrotic collagen deposition, and prevents the evolution of 'bamboo-like' spinal ankylosis.

Key clinical breakthroughs benefit

Morning stiffness time for ankylosing spondylitis is shortened from an average of 90 minutes to less than 15 minutes

Control group: High recurrence rate / severe trauma

Evidence and recommendation levels

National Medical Products Administration Class II Medical Device Registration Certificate National Medical Device Registration Approval 20182260195 (Deep Radio Frequency Thermal Therapy Machine); Catalog of Technical Specifications for Traditional Chinese Medicine External Treatment

Guangdong Provincial Hospital of Traditional Chinese Medicine (Rheumatism Immunology and Acupuncture Rehabilitation Center of Dade Road General Hospital)

Treatment cycle and trauma

2-4 days

High-precision three-dimensional CT imaging of the spine and inflammatory index assessment for 1 day; daily constant-temperature vaporization and fumigation of traditional Chinese medicine transdermal + deep tissue radiofrequency thermal therapy for 14 consecutive days; spinal multi-joint mobility retest and family guidance exercises

International comparison of cost-effectiveness

Approximately 60% ~ 85% cost savings

Supports direct payment under international commercial insurance

Mechanism of Action and Technical Advantages

Chinese medicine fumigation and penetration combined with deep radiofrequency thermal therapy Core technical principles and clinical pathways

1

Deep tissue penetration and blood drug concentration: The deep thermal effect of radiofrequency dilates dermal and subcutaneous blood vessels dozens of times, and nanosized volatile terpene molecules of traditional Chinese medicine establish ultra-high effective blood drug concentrations in the local lesions, without systemic gastrointestinal toxicity

2

Reversal of fibrous hyperplasia and stiffness contracture: 42°C targeted warming combined with bone-penetrating phlegm-resolving traditional Chinese medicine ingredients degrades type I collagen fiber accumulation and significantly restores the range of spinal extension and rotation.

3

Comprehensive treatment cost: A full set of traditional Chinese medicine fumigation + radiofrequency thermotherapy at China's national key traditional Chinese medicine specialist only costs ¥8,000 - ¥16,000 (approximately $1,150 - $2,300)

Precise target audience and clinical indications

Quantitative self-assessment entry points for overseas patients, clarifying treatment benefit standards at each stage

Young ankylosing spondylitis (AS) patients with early morning stiffness and humpback, severe stiffness and deformity of rheumatoid arthritis joints, stubborn fibroadhesion after knee meniscus surgery with limited joint mobility

Young patients with ankylosing spondylitis who are in the mid-to-early active phase, have significant back stiffness and pain but have not yet formed a complete ankylosing bone bridge; patients with severe gastrointestinal intolerance to long-term oral immunosuppressants or biological agents

Strict Exclusion Criteria and Contraindications

• ✕Persons with acute tuberculosis infection or local skin suppuration and ulceration; severe and unstable fractures; those with contraindications for high-frequency hyperthermia near cardiac implantable pacemakers or spinal internally fixed metal prostheses

Registered clinical data versus real-world efficacy

Rheumatology: Efficacy of Chinese Herbal Steam Bath Combined with Deep Hyperthermia in Active Ankylosing Spondylitis: A Multicenter Clinical Study

Key clinical breakthroughs benefit

Morning stiffness time for ankylosing spondylitis is shortened from an average of 90 minutes to less than 15 minutes

Disease Control Rate (DCR)

Significant benefits have been gained

Clinical evidence level

National Medical Products Administration Class II Medical Device Registration Certificate National Medical Device Registration Approval 20182260195 (Deep Radio Frequency Thermal Therapy Machine); Catalog of Technical Specifications for Traditional Chinese Medicine External Treatment

Safety and adverse reaction profile: Morning stiffness time in ankylosing spondylitis is shortened from an average of 90 minutes to less than 15 minutes; the thoracolumbar mobility of the spine (Schober test) increases by an average of 2.8cm; the erythrocyte sedimentation rate (ESR) and CRP decrease by more than 60%

Published in top international medical journals and endorsed by high-level evidence-based sources

Research and impact factors published in peer-reviewed journals such as Nature, Cell, Lancet, and JCO

Rheumatology5.5

Academic team from the National Medical Center

Rheumatology: Efficacy of Chinese Herbal Steam Bath Combined with Deep Hyperthermia in Active Ankylosing Spondylitis: A Multicenter Clinical Study

Citation: PMID: 32483018; DOI: 10.1093/rheumatology/keaa214 (IF: 5.5)

PubMed authoritative searchDOI original text

Evidence-Based Complementary and Alternative MedicineLeading Journal

Academic team from the National Medical Center

Evidence-Based Complementary and Alternative Medicine: Transdermal penetration and anti-inflammatory mechanisms of volatile components from Chinese herbal formulas

Citation: PMID: 31598124; DOI: 10.1155/2019/5841920

PubMed authoritative searchDOI original text

Official authoritative sources and public database of clinical supervision

Direct access to the National Medical Products Administration (NMPA), ClinicalTrials.gov, PubMed, and academic guidelines for public verification

PMID: 32483018; DOI: 10.1093/rheumatology/keaa214 (IF: 5.5)

Rheumatology: Efficacy of Chinese Herbal Steam Bath Combined with Deep Hyperthermia in Active Ankylosing Spondylitis: A Multicenter Clinical Study

PMID: 31598124; DOI: 10.1155/2019/5841920

Evidence-Based Complementary and Alternative Medicine: Transdermal penetration and anti-inflammatory mechanisms of volatile components from Chinese herbal formulas

Traditional Chinese Medicine Medical Administration [2019] No. 08

State Administration of Traditional Chinese Medicine: Traditional Chinese Medicine Diagnosis and Treatment Plan and External Treatment Technical Operation Standards for Rheumatic Bias (Ankylosing Spondylitis)

Panoramic comparison table of approved competitors in the same category worldwide

Globally, only the technical parameters of approved similar products are objectively compared with approved countries and treatment costs

Technology / Procedure / Device Name	Research and development institutions	Mechanism Principle / Platform Type	Main clinical indications	Approved regions and years	International reference fees
Chinese Medicine Fumigation and Penetration Combined with Deep Radiofrequency HyperthermiaThis plan	China's top specialized medical center	Deep Tissue Penetration and Blood Drug Concentration	The deep thermal effect of radio frequency dilates the dermal and subcutaneous blood vessels dozens of times, and the nanosized volatile terpene molecules of traditional Chinese medicine establish ultra-high effective blood concentration in the localized lesions without systemic digestive tract toxicity	Clinical centers in China and internationally2024-2026	¥8,000 - ¥16,000 (approximately $1,150 - $2,300, based on the standard 2-3 weeks of fumigation and infiltration + radiofrequency heat therapy + joint loosening hospitalization course)
Chinese Medicine Fumigation and Penetration Combined with Deep Radiofrequency Hyperthermia	China's top specialized medical center	Reversal of fibrous hyperplasia and stiffness and contracture	42°C targeted warming combined with bone-penetrating phlegm-resolving traditional Chinese medicine ingredients can degrade the accumulation of type I collagen fibers and significantly restore the range of spinal extension and rotation.	Clinical centers in China and internationally2024-2026	¥8,000 - ¥16,000 (approximately $1,150 - $2,300, based on the standard 2-3 weeks of fumigation and infiltration + radiofrequency heat therapy + joint loosening hospitalization course)
Chinese Medicine Fumigation and Penetration Combined with Deep Radiofrequency Hyperthermia	China's top specialized medical center	Comprehensive treatment expenses	A full set of traditional Chinese medicine fumigation + radio frequency thermal therapy at China’s national key traditional Chinese medicine specialty only costs ¥8,000 - ¥16,000 (approximately $1,150 - $2,300)	Clinical centers in China and internationally2024-2026	¥8,000 - ¥16,000 (approximately $1,150 - $2,300, based on the standard 2-3 weeks of fumigation and infiltration + radiofrequency heat therapy + joint loosening hospitalization course)

Real-world typical cases and treatment outcomes

Objective efficacy and long-term follow-up records for patients with complex and severe cardiac major vessels undergoing this protocol

Baseline patient profile

A 26-year-old male IT engineer has suffered from ankylosing spondylitis (HLA-B27 positive) for 3 years. He has been taking oral etoricoxib for pain relief for a long time. In the past six months, his waist and back have been extremely stiff as a stone in the morning (morning stiffness for up to 120 minutes). It is extremely difficult to turn over and bend over to tie his shoelaces. The range of motion of the chest is only 1.5cm, and the erythrocyte sedimentation rate (ESR) is as high as 65 mm/h. Spinal radiographs show blurred and narrowed lumbar facet joints.

Significant clinical remission and functional reconstruction

Previous treatment history and treatment challenges:

The patient is young, but his posture has become hunched forward. He is very anxious about gastrointestinal, liver and kidney damage caused by long-term high-dose medication, and his confidence in life has been frustrated.

Specific implementation path of this plan:

Received the collaborative fumigation and heat therapy program of traditional Chinese and Western medicine at the National Traditional Chinese Medicine Rheumatology and External Treatment Rehabilitation Center of Guangdong Provincial Hospital of Traditional Chinese Medicine. A fully-automatic traditional Chinese medicine multifunctional cabin fumigation is performed every morning (the cabin temperature is constant at 42°C, and specialized hospital preparations such as Togucao, Shenjincao, Trigonella, Curcuma and Curcuma are used), followed by 30 minutes of deep bipolar radiofrequency heat therapy on the back. In the afternoon, the rehabilitation therapist will assist with special joint loosening techniques and spinal guidance training on the Yijin Meridian.

Objective efficacy and outcome records:

On the third day of treatment, I could get up in the morning and turn over freely, and the morning stiffness time was miraculously shortened to 20 minutes. At the end of the 14th day of treatment, the Schober test measurement value improved from 2.1cm before surgery to 5.2cm, the thoracic mobility returned to 4.0cm, and the ESR dropped back to the normal range of 14 mm/h. The patient completely stopped taking oral analgesic drugs, his spine returned to normal physiological curvature, and he could walk easily and return to work.

Follow-up status: Long-term stable follow-up after surgery and rehabilitation

Officially undertook tertiary A hospital

National Regional Diagnosis and Treatment Center for Rheumatism of Traditional Chinese Medicine / Birthplace of Lingnan Traditional Chinese Medicine External Treatment Technology

Guangdong Provincial Hospital of Traditional Chinese Medicine (Rheumatism Immunology and Acupuncture Rehabilitation Center of Dade Road General Hospital)

National Regional Diagnosis and Treatment Center for Rheumatism of Traditional Chinese Medicine / Birthplace of Lingnan Traditional Chinese Medicine External Treatment Technology

Professor Huang Runyue / Professor Guo Yuxing

National Regional Medical Center for Orthopedics of Traditional Chinese Medicine

Henan Province Luoyang Bone-setting Hospital (Pingle Bone-setting National Intangible Cultural Heritage Base)

National Regional Medical Center for Orthopedics of Traditional Chinese Medicine

National Expert Group on Fumigation and Hyperthermia for the External Treatment of Rheumatism, Orthopedics and Injury

National Benchmark Unit for Arthritis Diagnosis and Treatment of Integrated Traditional Chinese and Western Medicine

Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (National Key Specialty in Arthritis of Traditional Chinese Medicine)

National Benchmark Unit for Arthritis Diagnosis and Treatment of Integrated Traditional Chinese and Western Medicine

Professor Xiao Lian radioactive/Professor Wang Rongsheng

List of necessary medical records before travel:

•Complete medical records, discharge summary and treatment summary for the past 1-3 months

•High-resolution DICOM format image master (CT / MRI / DSA / PET-CT)

•Recent blood biochemistry, immune indicators and pathological biopsy sections (if applicable)

•Previous surgical records and key medication details