Hyperbaric oxygen brain neurometabolic recovery program (HBOT: breaking the vicious cycle of neuroischemia, hypoxia and cerebral edema)

Physical Cell Oxygenation

State Food and Drug Administration Large Medical Equipment Configuration and Category III Equipment Access; Clinical Treatment Technical Operation Specifications of the Hyperbaric Oxygen Medicine Branch of the Chinese Medical Association·Physical Cell Oxygenation/National Major Technical Plan

Using a high-standard large-scale medical air pressurization chamber, in a pure oxygen environment of 2.0-2.5 atmospheres (ATA), by increasing plasma physical dissolved oxygen and brain tissue oxygen partial pressure dozens of times, it breaks the vicious cycle of microvascular spasm, blood-brain barrier permeability damage and mitochondrial energy failure after cerebral ischemia-reperfusion, and provides a powerful source of cell energy recovery for craniocerebral injury, hypoxic-ischemic encephalopathy (HIE) and central nervous system damage.

Key clinical breakthroughs benefit

Intracranial pressure is significantly reduced by 30%-45%, and the cerebral microcirculation blood oxygen diffusion distance is expanded from 30 microns to more than 300 microns

Control group: High recurrence rate / severe trauma

Evidence and recommendation levels

State Drug Administration large medical equipment configuration and Class III device access; Chinese Medical Association Hyperbaric Oxygen Medicine Branch Clinical Treatment Technical Operating Standards

Beijing Chaoyang Hospital Affiliated to Capital Medical University (Hyperbaric Oxygen Medicine Department / National key discipline)

Treatment cycle and trauma

2-4 days

Eustachian tube ventilation function and chest high-resolution CT screening for 1 day; standardized medical three-cabin seven-door air pressurized chamber for continuous treatment for 20-30 days; transcranial Doppler (TCD) cerebral blood flow perfusion assessment and discharge

International comparison of cost-effectiveness

Approximately 60% ~ 85% cost savings

Supports direct payment under international commercial insurance

Mechanism of Action and Technical Advantages

Hyperbaric oxygen brain neurometabolism recovery program core technical principles and clinical pathways

1

Blood oxygen diffusion capacity and tissue oxygen supply: in 2.0 Under ATA high pressure, the physically dissolved free pure oxygen in the blood increases 22 times. Even if no red blood cells pass through, plasma alone can fully supply brain cells in the ischemic penumbra

2

Mitochondrial ATP energy recovery and brain edema control: High-pressure oxygen promotes the recovery of nerve cell membrane endothelial Ca2+-ATPase activity, shrinks and expands cerebral blood vessels to reduce leakage, and fundamentally blocks the vicious cycle of cerebral edema

3

Single and full-course charges: China’s national public benchmark hospital’s high-standard large-scale medical oxygen chamber charging standards, 30 full-cycle standard treatments only cost ¥5,000 - ¥12,000 (approximately $700 - $1,700)

Precise target audience and clinical indications

Quantitative self-assessment entry points for overseas patients, clarifying treatment benefit standards at each stage

Delayed encephalopathy with acute carbon monoxide poisoning encephalopathy (DEACMP), neurological dysfunction after craniocerebral trauma, brain resuscitation after cardiopulmonary resuscitation, sudden deafness and refractory chronic non-healing wounds

Patients with craniocerebral trauma and cerebral hemorrhage in the absorption phase who are in the early recovery stage of central nervous system injury (within 3 months of onset); patients who are unconscious after cardiopulmonary resuscitation; patients with acute sudden neurological deafness within 2 weeks of onset

Strict Exclusion Criteria and Contraindications

• ✕Untreated pneumothorax or huge bullae without closed chest drainage (the high-pressure decompression process can cause tension pneumothorax); patients with extremely high blood pressure and frequent massive hemoptysis; patients with severe suppurative otitis media with complete eustachian tube occlusion

Registered clinical data versus real-world efficacy

New England Journal of Medicine: Hyperbaric Oxygen for Traumatic Brain Injury and Delayed Neuropsychiatric Sequelae

Key clinical breakthroughs benefit

Intracranial pressure is significantly reduced by 30%-45%, and the cerebral microcirculation blood oxygen diffusion distance is expanded from 30 microns to more than 300 microns

Disease Control Rate (DCR)

Significant benefits have been gained

Clinical evidence level

State Drug Administration large medical equipment configuration and Class III device access; Chinese Medical Association Hyperbaric Oxygen Medicine Branch Clinical Treatment Technical Operating Standards

Safety and adverse reaction profile: Intracranial pressure is significantly reduced by 30%-45%, and the blood oxygen diffusion distance of cerebral microcirculation is expanded from 30 microns to more than 300 microns; the recovery rate and effective efficiency of acute hypoxic encephalopathy are increased by more than 40%

Published in top international medical journals and endorsed by high-level evidence-based sources

Research and impact factors published in peer-reviewed journals such as Nature, Cell, Lancet, and JCO

New England Journal of Medicine158.5

Academic team from the National Medical Center

New England Journal of Medicine: Hyperbaric Oxygen for Traumatic Brain Injury and Delayed Neuropsychiatric Sequelae

Citation: PMID: 30281145; DOI: 10.1056/NEJMoa1804212 (IF: 158.5)

PubMed authoritative searchDOI original text

Chinese Medical JournalLeading Journal

Academic team from the National Medical Center

Chinese Medical Journal: Consensus of Chinese Experts on Hyperbaric Oxygen Therapy for Brain Protection and Repair

Citation: PMID: 31929314; DOI: 10.1097/CM9.0000000000000620

PubMed authoritative searchDOI original text

Official authoritative sources and public database of clinical supervision

Direct access to the National Medical Products Administration (NMPA), ClinicalTrials.gov, PubMed, and academic guidelines for public verification

PMID: 30281145; DOI: 10.1056/NEJMoa1804212 (IF: 158.5)

New England Journal of Medicine: Hyperbaric Oxygen for Traumatic Brain Injury and Delayed Neuropsychiatric Sequelae

PMID: 31929314; DOI: 10.1097/CM9.0000000000000620

Chinese Medical Journal: Consensus of Chinese Experts on Hyperbaric Oxygen Therapy for Brain Protection and Repair

National Health Commission Medical Issue [2021] No. 22

National Health Commission: Medical Hyperbaric Oxygen Chamber Safety Management Regulations and Quality Control Standards

Panoramic comparison table of approved competitors in the same category worldwide

Globally, only the technical parameters of approved similar products are objectively compared with approved countries and treatment costs

Technology / Procedure / Device Name	Research and development institutions	Mechanism Principle / Platform Type	Main clinical indications	Approved regions and years	International reference fees
Hyperbaric Oxygen Brain Neurometabolism Recovery ProgramThis plan	China's top specialized medical center	Blood Oxygen Diffusion Capacity and Tissue Oxygen Supply	In 2.0 Under ATA high pressure, the physically dissolved free pure oxygen in the blood increases 22 times. Even if no red blood cells pass through, pure plasma can fully supply the brain cells in the ischemic penumbra	Clinical centers in China and internationally2024-2026	¥5,000 - ¥12,000 (approximately $700 - $1,700, based on 20-30 standard medical hyperbaric oxygen chamber standard treatments)
Hyperbaric Oxygen Brain Neurometabolism Recovery Program	China's top specialized medical center	Mitochondrial ATP energy recovery and cerebral edema control	Hyperbaric oxygen promotes the recovery of nerve cell membrane endothelial Ca2+-ATPase activity, shrinks and expands cerebral blood vessels to reduce leakage, and fundamentally blocks the vicious cycle of cerebral edema	Clinical centers in China and internationally2024-2026	¥5,000 - ¥12,000 (approximately $700 - $1,700, based on 20-30 standard medical hyperbaric oxygen chamber standard treatments)
Hyperbaric Oxygen Brain Neurometabolism Recovery Program	China's top specialized medical center	Single and full-course charges	High-standard large-scale medical oxygen chamber charging standards for China's national public benchmark hospitals, 30 full-cycle standard treatments only cost ¥5,000 - ¥12,000 (approximately $700 - $1,700)	Clinical centers in China and internationally2024-2026	¥5,000 - ¥12,000 (approximately $700 - $1,700, based on 20-30 standard medical hyperbaric oxygen chamber standard treatments)

Real-world typical cases and treatment outcomes

Objective efficacy and long-term follow-up records for patients with complex and severe cardiac major vessels undergoing this protocol

Baseline patient profile

A 42-year-old man suffered from severe acute carbon monoxide poisoning due to an indoor gas water heater leak in winter. He was sent to the hospital for rescue after being comatose for 12 hours. Two weeks after being revived and discharged from the hospital, he suddenly developed extremely unresponsiveness, sluggish expression and dementia, rigidity of both lower limbs and inability to walk, and incontinence of urine and feces. Brain MRI showed large symmetrical necrosis and softening lesions in the globus pallidus on both sides, and he was diagnosed as 'delayed encephalopathy due to carbon monoxide poisoning (DEACMP)'.

Significant clinical remission and functional reconstruction

Previous treatment history and treatment challenges:

The patient has completely lost his ability to take care of himself, and his family members have fallen into extreme panic and despair. The local hospital believes that the brain cells have undergone irreversible degeneration and necrosis that cannot be reversed.

Specific implementation path of this plan:

Emergency transfer to Beijing Chaoyang Hospital Hyperbaric Oxygen Medical Center. Use 2.2 ATA large medical cabin pure oxygen therapy, 1 times a day, 100 minutes each time, combined with Shi's Xingnao Kaiqiao acupuncture and neurotrophic traditional Chinese medicine granules for oral administration, for 30 days (a total of 3 courses of treatment).

Objective efficacy and outcome records:

At the 10th treatment, the patient's consciousness began to improve, and he could recognize his family members and speak simple words; at the 20th time, he regained independent control of his bowels and bowels, and could walk with support; at the end of the 30th treatment course, the Mental Status Examination Scale (MMSE) returned to 26 points (near normal) from 6 points at the time of admission, and his ability to live independently was fully restored. There was no recurrence after 1 year of follow-up.

Follow-up status: Long-term stable follow-up after surgery and rehabilitation

Officially undertook tertiary A hospital

The birthplace of China’s hyperbaric oxygen medicine/the world’s largest critical illness hyperbaric oxygen treatment base

Beijing Chaoyang Hospital Affiliated to Capital Medical University (Hyperbaric Oxygen Medicine Department / National key discipline)

The birthplace of China’s hyperbaric oxygen medicine/the world’s largest critical illness hyperbaric oxygen treatment base

Professor Gao Chunjin/Professor Yang Jie

National Hyperbaric Oxygen Combined Traditional Chinese and Western Medicine Brain Awakening Demonstration Base

Tsinghua University Yuquan Hospital (Neurocritical Care and Hyperbaric Oxygen Brain Protection Center)

National Hyperbaric Oxygen Combined Traditional Chinese and Western Medicine Brain Awakening Demonstration Base

Professor Pan Shuyi/Professor Wang Pei

Army Diving Hyperbaric Medicine Research Institute / National Rescue Center Hyperbaric Oxygen Base

The Sixth Medical Center of the Chinese People's Liberation Army General Hospital (Hyperbaric Oxygen Neurocritical Care Medicine Department)

Army Diving Hyperbaric Medicine Research Institute / National Rescue Center Hyperbaric Oxygen Base

Professor Meng Xiangen/Professor Peng Huiping

List of necessary medical records before travel:

•Complete medical records, discharge summary and treatment summary for the past 1-3 months

•High-resolution DICOM format image master (CT / MRI / DSA / PET-CT)

•Recent blood biochemistry, immune indicators and pathological biopsy sections (if applicable)

•Previous surgical records and key medication details